Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7063 | 7063-30708 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V, L90M | L10FI, V11VI, L89V | T12E, I13V, K20I, E34Q, D60E, I62IV, L63P, A71V, I72L, T91TA, Q92K |
| >7063-30708| codons 1-99 PQITLWQRPIIEVKIGGQLIEALLDTGADDTVLQEMNLPGRWKPKIIGGIGGFVKVRQYE QVPIEICGHKVLGTVVVGPTPVNVIGRNVMAKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215Y | V75I, K219E | K103KN, Y181C, G190A | K101H, F227L | K11R, K20R, V35R, K49R, I50V, K122E, I135T, P170S, D218E, K223T, L228HR, T286A, E297K, M357T, T369V, E370D, A376T |
| >7063-30708| codons 1-399 PISPIETVPVRLKPGMDGPRVKQWPLTEEKIKALREICTELEKEGKISRVGPENPYNTPV FAIKKKNSTRWRKLIDFRELNKRTQDFWEVQLGIPHPAGLHKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILESFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIEELRQHLWRWGFYTPEEKHQTEPPLRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLVDAVQKITTESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |