Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7055 | 7055-30714 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | Y181C, G190A | A98G | T39TA, K43N, E44D, K101Q, V118I, D123EG, E203EK, Q207K, H208Y, R211D, K223Q, E248ED, S251I, A272P, K275R, I293V, T296S, K390KR |
| >7055-30714| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLQKKKSVTVLDVGDAYFSIPL DKGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIKELRKYLWDWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIVLPDKDIWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKALTEVVPLSEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54A, V82A | L24I, L33F, K43T | L10I, E34Q, M36L, R41RK, D60E, I62V, L63P, A71V, Q92K |
| >7055-30714| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVFQELNLPGKWTPKLIGGIGGFAKVRQYE QVPIEICGHKVIGTVLVGPTPANIIGRNLLTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |