<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7055 7055-30714 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54A, V82A L24I, L33F, K43T L10I, E34Q, M36L, R41RK, D60E, I62V, L63P, A71V, Q92K  
>7055-30714| codons 1-99
PQITLWQRPIVTIKIGGQLKEALIDTGADDTVFQELNLPGKWTPKLIGGIGGFAKVRQYE
QVPIEICGHKVIGTVLVGPTPANIIGRNLLTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y   Y181C, G190A A98G T39TA, K43N, E44D, K101Q, V118I, D123EG, E203EK, Q207K, H208Y, R211D, K223Q, E248ED, S251I, A272P, K275R, I293V, T296S, K390KR  
>7055-30714| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELENDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLQKKKSVTVLDVGDAYFSIPL
DKGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVASDLEIGQHRTKIKELRKYLWDWGFYTPDKKHQQEPPFLWMGYELHPDKWT
VQPIVLPDKDIWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKALTEVVPLSEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006