Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7049 | 7049-30429 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82A | L33F | L10I, K20T, E35D, M36I, N37S, R41K, R57K, I62V, L63P, I93L |
| >7049-30429| codons 1-99 PQITLWQRPIVTIKIGGQLTEALLDTGADDTVFEDISLPGKWKPKLIGGIGGFLKVKQYD QVPIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219EQ | K103KNRS, G190A | A98AS, V118I, K122E, D123E, R172RK, D177E, I178M, H208HY, F214L, L228LH, A272P, A288S, E297Q, G335C, M357T, G359S, A371V, T386TA, K390R |
| >7049-30429| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKSKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPEMVI YQYMDDLYVASDLEIGQHRTKIEELRQYLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVIPLTQEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQCQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLTEVVQKIATESIVIWGKAPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |