Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7043 | 7043-30925 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | N88ND | L10I, T12P, I15V, L19I, K20KT, K45R, I62V, L63P, C67CY, A71T, I72IM, V77I, I93L |
| >7043-30925| codons 1-99 PQITLWQRPIVPIKVGGQITEALLDTGADDTVLEEMNLPGRWKPRMIGGIGGFIKVRQYD QVPIEIYGHKTMGTVLIGPTPVNIIGRDLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, T215SY | K219N, N348I | K103N, Y181C | T39A, K49R, K122E, I135T, E169D, Q174R, G196E, I202V, Q207E, H208HY, R211K, A272P, A288S, I293V, I309IL, K311KR, G333E, Q334HY, G359S, T386TI, K390R, E399G |
| >7043-30925| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISRIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKRNPDIVI CQYMDDLYVGSDLEIEQHRTKVEELREYLLKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVVPLTEEAE LELAENRELLREPVHGVYYDPSKDLIAEIQKQEYGQWTYQIYQEPFKILKTGKYARMRSA HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWGA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |