Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7039 | 7039-30918 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, T215F | K219Q | K101E, Y181C, G190S | K20R, V35L, T39E, K64H, T69N, K122E, S162D, D177E, I178M, G196E, T200A, E204D, D218E, A272P, Q278H, E297K, I326V, G359S, A371V, I375V, A376S, T377Q, K390R |
| >7039-30918| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICEELEKEGKISKIGPENPYNTPV FAIHKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPEMVI CQYMDDLYVSSDLEIEQHRAKIEDLRQHLLRWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKHLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKVSQESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10F, L33F | K20R, E35D, M36I, N37E, R41K, I62V, L63P, A71V, I93L |
| >7039-30918| codons 1-99 PQITLWQRPFVTIKIGGQLREALLDTGADDTVFEDIELPGKWKPKMIGGIGGFVKVRQYD QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |