<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7034 7034-30812 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y V75L, K219N L100I, K103N   E6K, V35I, E40F, K43E, V118I, K122E, I135T, K166R, D177N, G196E, T200A, H208Y, R211K, K223Q, L228H, A272P, L283LI, P294Q, Q334N, G335S, K350R, R356K, R358K, K366R, A376V, S379C, T386M, K390R, E399D  
>7034-30812| codons 1-399
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTFLEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPNIVI
YQYMDDLYVGSDLEIEQHRAKIEELRQYLWKWGFYTPDNKHQQEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIQLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNSQWTYQIYQEPFKNLRTGKYAKMKGA
HTNDVRQLTEAVQKIVTECIVIWGKMPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, I84V, L90M L33I, G73S, L89V L10I, V11L, I13V, I15V, K20I, M36I, K55KR, R57RK, I62V, L63P, A71V, I72M  
>7034-30812| codons 1-99
PQITLWQRPILTVKVGGQLIEALLDTGADDTVIEEINLPGRWKPKIIGGIGGFVRVKQYD
QVPIEICGHKVMSTVVVGPTPVNVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006