Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7034 | 7034-30812 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V, L90M | L33I, G73S, L89V | L10I, V11L, I13V, I15V, K20I, M36I, K55KR, R57RK, I62V, L63P, A71V, I72M |
| >7034-30812| codons 1-99 PQITLWQRPILTVKVGGQLIEALLDTGADDTVIEEINLPGRWKPKIIGGIGGFVRVKQYD QVPIEICGHKVMSTVVVGPTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V75L, K219N | L100I, K103N | E6K, V35I, E40F, K43E, V118I, K122E, I135T, K166R, D177N, G196E, T200A, H208Y, R211K, K223Q, L228H, A272P, L283LI, P294Q, Q334N, G335S, K350R, R356K, R358K, K366R, A376V, S379C, T386M, K390R, E399D |
| >7034-30812| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPNIVI YQYMDDLYVGSDLEIEQHRAKIEELRQYLWKWGFYTPDNKHQQEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIQLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNSQWTYQIYQEPFKNLRTGKYAKMKGA HTNDVRQLTEAVQKIVTECIVIWGKMPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |