Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7028 | 7028-30710 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Y115F, Q151M, M184V | V75I, F77L, F116Y | K103N | V35I, T58S, S68G, V111I, V118VI, D123E, S163SC, D177E, I178L, T200K, F214C, H221Y, A272P, K277R, E297K, Q334E, A376T, T386I | N137S, L234LP |
| >7028-30710| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNSPV FAIKRKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDIGDAFYSIPL DKEFRKYTAFTIPSINSETPGIRYQYNVLPMGWKGSPAIFQSCMTKILEPFRKQNPELVI YQYVDDLYVGSDLEIGQHRKKIEELRQHLLRWGCTTPDKKYQKEPPFLWMGYEPHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKITTESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L33F, Q58E, G73S | T4A, L19I, E35D, M36L, N37S, I62V, L63P, I66L, C67F, H69R, A71V, I72L, V77I, I85V, C95V |
| >7028-30710| codons 1-99 PQIALWQRPFVTIKIGGQIKEALLDTGADDTVFEDLSLPGRWKPKIIGGIGGFVKVREYD QVPIELFGRKVLSTVLIGPTPVNVVGRNLMTQIGVTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |