<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7028 7028-30710 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, L33F, Q58E, G73S T4A, L19I, E35D, M36L, N37S, I62V, L63P, I66L, C67F, H69R, A71V, I72L, V77I, I85V, C95V  
>7028-30710| codons 1-99
PQIALWQRPFVTIKIGGQIKEALLDTGADDTVFEDLSLPGRWKPKIIGGIGGFVKVREYD
QVPIELFGRKVLSTVLIGPTPVNVVGRNLMTQIGVTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Y115F, Q151M, M184V V75I, F77L, F116Y K103N   V35I, T58S, S68G, V111I, V118VI, D123E, S163SC, D177E, I178L, T200K, F214C, H221Y, A272P, K277R, E297K, Q334E, A376T, T386I N137S, L234LP
>7028-30710| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNSPV
FAIKRKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDIGDAFYSIPL
DKEFRKYTAFTIPSINSETPGIRYQYNVLPMGWKGSPAIFQSCMTKILEPFRKQNPELVI
YQYVDDLYVGSDLEIGQHRKKIEELRQHLLRWGCTTPDKKYQKEPPFLWMGYEPHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKIPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006