<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7026 7026-30918 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219KQ K101E, Y181C, G190A   K20R, E28EK, K32KE, T39A, K43KNRS, K64KR, V118I, K122E, D123E, I135T, Q145V, K166R, D177E, D218E, A272P, L283I, I293V, E297EQ, D324DE, I329V, M357R, R358K, A371V, T386I  
>7026-30918| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALVEICAELESEGKISKIGPENPYNTPV
FAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSTNNETPGIRYVYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI
CQYVDDLYVASDLEIGQHRTKIEELRQHLWRWGFYTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTQEAE
LELAENREILKEPVHGVYYDPSKELIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARRKGA
HTNDVKQLTEVVQKIATESIVIWGKIPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M F53L, G73C L10V, I15V, G16A, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, Q61E, I62V, L63P  
>7026-30918| codons 1-99
PQITLWQRPVVTIKVAGQLREALLDTGADDTVLEDIDLPGKWKPKLIGGIGGLVRVKQYD
EVPIEICGHKAICTVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006