Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7026 | 7026-30918 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | F53L, G73C | L10V, I15V, G16A, K20R, E35D, M36I, N37D, R41K, K55R, R57RK, Q61E, I62V, L63P |
| >7026-30918| codons 1-99 PQITLWQRPVVTIKVAGQLREALLDTGADDTVLEDIDLPGKWKPKLIGGIGGLVRVKQYD EVPIEICGHKAICTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219KQ | K101E, Y181C, G190A | K20R, E28EK, K32KE, T39A, K43KNRS, K64KR, V118I, K122E, D123E, I135T, Q145V, K166R, D177E, D218E, A272P, L283I, I293V, E297EQ, D324DE, I329V, M357R, R358K, A371V, T386I |
| >7026-30918| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALVEICAELESEGKISKIGPENPYNTPV FAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYVYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI CQYVDDLYVASDLEIGQHRTKIEELRQHLWRWGFYTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTQEAE LELAENREILKEPVHGVYYDPSKELIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARRKGA HTNDVKQLTEVVQKIATESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |