Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7024 | 7024-30915 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, T215Y | K219Q, N348I | K103KNRS, Y181C | K11KE, V35M, T39TA, V60I, D123E, I135T, D177E, I178M, G196E, H208Y, R211K, H221Y, L228H, A272P, K277R, T286A, I293V, M357T, A360T, T386I, K390KR |
| >7024-30915| codons 1-398 PISPIETVPVELKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI CQYMDDLYVGSDLEIEQHRTKIEELRQYLLKWGFYTPDQKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARTRGT HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V | L24I, L33F | L10I, R41K, F53FY, K55R, L63P, A71V, T91S |
| >7024-30915| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVFEEMNLPGKWKPKIIGGIGGYVRVRQYD QIPIEICGHKVIGTVLVGPTPTNVIGRNLLSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |