<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7023 7023-40109 Spain 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 17

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, L210W, T215Y   Y181C, G190S K101H E6K, T39K, K43E, E44D, K102R, V118I, K122E, I142V, V189VI, I195IR, G196E, T200A, E203K, Q207D, H208Y, R211K, K223E, L228R, R284K, T286A, P294T, E297R, S322T, I329V, Q334E, M357T, G359GS  
>7023-40109| codons 1-399
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEDGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLHRKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYISSDLEREQHRAKIKELRDYLWKWGFYTPDKKHQEEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKALTEVITLTREAE
LELAENREILKEPVHGVYYDPTKDLIAEVQKQGEGQWTYQIYQEPFKNLKTGKYARTRSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82F, L90M F53L, Q58E L10I, K20R, E35D, M36V, N37E, I62V, L63P, I64V, A71V, T74S, V77I, I85V, I93L  
>7023-40109| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDVELPGRWKPKMIGGIGGLVKVREYD
QVPVEICGHKVIGSVLIGPTPFNIVGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006