Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7023 | 7023-40109 | Spain | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 17 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | Y181C, G190S | K101H | E6K, T39K, K43E, E44D, K102R, V118I, K122E, I142V, V189VI, I195IR, G196E, T200A, E203K, Q207D, H208Y, R211K, K223E, L228R, R284K, T286A, P294T, E297R, S322T, I329V, Q334E, M357T, G359GS |
| >7023-40109| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEDGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLHRKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYISSDLEREQHRAKIKELRDYLWKWGFYTPDKKHQEEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKALTEVITLTREAE LELAENREILKEPVHGVYYDPTKDLIAEVQKQGEGQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82F, L90M | F53L, Q58E | L10I, K20R, E35D, M36V, N37E, I62V, L63P, I64V, A71V, T74S, V77I, I85V, I93L |
| >7023-40109| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDVELPGRWKPKMIGGIGGLVKVREYD QVPVEICGHKVIGSVLIGPTPFNIVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |