<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7023 7023-30915 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82F, L90M F53L, Q58E L10I, K20R, E35D, M36V, N37E, I62V, L63P, I64V, A71V, T74S, V77I, I85V, I93L  
>7023-30915| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDVELPGRWKPKMIGGIGGLVKVREYD
QVPVEICGHKVIGSVLIGPTPFNIVGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, L210W, T215Y   Y181C, G190S K101H E6K, T39K, K43E, E44ED, K102R, V118I, K122E, I142V, V189I, G196E, T200A, E203K, Q207DE, H208Y, R211K, K223E, L228R, R284K, T286A, P294T, E297R, S322T, I329V, Q334E, M357T  
>7023-30915| codons 1-399
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEDGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLHRKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYISSDLEIEQHRAKIKELREYLWKWGFYTPDKKHQEEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKALTEVITLTREAE
LELAENREILKEPVHGVYYDPTKDLIAEVQKQGEGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006