Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7022 | 7022-30915 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | A62V, N348I | K103N, Y181C | T39S, V90I, K101KR, K122E, I135T, T139R, G196E, K223Q, L228R, V245K, L283I, R284K, I293V, P294A, E297K, Q334N, T338S, A376AS |
| >7022-30915| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICSELEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLRKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNERPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPDKKHQQEPPFRWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIKGTKALTEVVALTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNGQWSYQIYQEPFKILKTGKYARMRGA HTNDVKQLTEAVQKISTESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L33F, Q58QE | L10I, T12P, K14R, E35D, M36I, N37D, D60E, Q61H, I62V, L63P, A71T, I72E, I93L |
| >7022-30915| codons 1-99 PQITLWQRPIVPIRIGGQLKEALLDTGADDTVFEDIDLPGRWKPKMIGGIGGFVKVREYE HVPIEICGHKTEGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |