<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7022 7022-30915 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M L33F, Q58QE L10I, T12P, K14R, E35D, M36I, N37D, D60E, Q61H, I62V, L63P, A71T, I72E, I93L  
>7022-30915| codons 1-99
PQITLWQRPIVPIRIGGQLKEALLDTGADDTVFEDIDLPGRWKPKMIGGIGGFVKVREYE
HVPIEICGHKTEGTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L210W, T215Y A62V, N348I K103N, Y181C   T39S, V90I, K101KR, K122E, I135T, T139R, G196E, K223Q, L228R, V245K, L283I, R284K, I293V, P294A, E297K, Q334N, T338S, A376AS  
>7022-30915| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICSELEKEGKISKIGPENPYNTPV
FVIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLRKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNERPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPDKKHQQEPPFRWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIKGTKALTEVVALTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNGQWSYQIYQEPFKILKTGKYARMRGA
HTNDVKQLTEAVQKISTESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006