<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7021 7021-30825 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, L210W, T215Y   K101E, Y181C, G190S   V35I, K43E, E44A, V118I, K122E, D123E, D177E, T200K, E203D, Q207E, H208F, R211DN, E224D, L228H, V245E, A288S, I293V, E297K, D324E, M357K, A360V, V365I, Q367E, T377R, I380IV, K390R, E399D  
>7021-30825| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
CQYMDDLYVSSDLEIGQHRKKIDELREFLWNWGFYTPDKKHQKDPPFHWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARKRGV
HTNDIKELTEAVQKIARESVVIWGKTPKFRLPIQKETWDA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48M, I54S, V82S L24I, L33F, Q58E L10I, G16A, E34Q, E35D, M36I, N37D, R57RK, I62V, L63P, A71V, I72IV, Q92K  
>7021-30825| codons 1-99
PQITLWQRPIVTIKIAGQLKEALIDTGADDTVFQDIDLPGRWKPKMIMGIGGFSKVKEYD
QVPIEICGHKVVGTVLVGPTPSNIIGRNLLTKIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006