Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7021 | 7021-30825 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54S, V82S | L24I, L33F, Q58E | L10I, G16A, E34Q, E35D, M36I, N37D, R57RK, I62V, L63P, A71V, I72IV, Q92K |
| >7021-30825| codons 1-99 PQITLWQRPIVTIKIAGQLKEALIDTGADDTVFQDIDLPGRWKPKMIMGIGGFSKVKEYD QVPIEICGHKVVGTVLVGPTPSNIIGRNLLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | K101E, Y181C, G190S | V35I, K43E, E44A, V118I, K122E, D123E, D177E, T200K, E203D, Q207E, H208F, R211DN, E224D, L228H, V245E, A288S, I293V, E297K, D324E, M357K, A360V, V365I, Q367E, T377R, I380IV, K390R, E399D |
| >7021-30825| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVSSDLEIGQHRKKIDELREFLWNWGFYTPDKKHQKDPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARKRGV HTNDIKELTEAVQKIARESVVIWGKTPKFRLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |