<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7016 7016-31216 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 22

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M G73T L10I, T12K, I15IV, L19I, K20I, M36MI, L63P, A71V, I72R, P79A, I93L  
>7016-31216| codons 1-99
PQITLWQRPIVKIKVGGQIIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD
QIPIEICGHKVRTTVLVGATPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L210W, T215Y D67G, K219R, N348I K103N, Y181C   K20R, V21I, T39TA, E40F, K43E, R83RK, V90I, V118I, K122E, I135T, S162Y, V179VI, R211K, L228R, A288G, E297K, E312Q, M357MT, A360AV, E370EA, T386TI, K390R  
>7016-31216| codons 1-399
PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALVEICAFLEEEGKISKIGPENPYNTPV
FAIKKKGSDKWRKLVDFRELNKKTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII
CQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDRKHQKEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKGLTEVIPLTKEAE
LELAENREILKQPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARTRGV
HTNDVKQLTAAVQKIATESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006