Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7016 | 7016-30716 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L210W, T215Y | D67G, K219R, N348I | K103N, Y181C | K20R, V21VI, V35VI, T39A, E40F, K43E, R83K, V90I, V118I, K122E, I135T, S162Y, V179VI, R211K, L228R, A288G, E297K, E312Q, M357T, K390R |
| >7016-30716| codons 1-399 PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALIEICAFLEEEGKISKIGPENPYNTPV FAIKKKGSDKWRKLVDFRELNKKTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII CQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDRKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKGLTEVIPLTKEAE LELAENREILKQPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | G73T | L10I, T12K, L19I, K20I, L63P, A71V, I72R, P79A, I93L |
| >7016-30716| codons 1-99 PQITLWQRPIVKIKIGGQIIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGHKVRTTVLVGATPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |