<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7013 7013-31230 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 24

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, Q151M, T215F F116Y, K219Q K103N, Y181C, G190A   V35VI, V60VI, V118I, K122E, M164L, Q174K, G196E, F214L, L228H, V245E, Q278N, A288T, I293V, K311R, Q334C, R356K, A360T, A376S, T377Q, S379C, K390R  
>7013-31230| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYYSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSLTKILEPFRKKNPDIVI
CQYMDDLYVASDLEIEQHRTKIEELRQHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKNLCKLLRGTKTLTEVVPLTEEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQGCGQWTYQIYQEPFKNLKTGKYAKMRGT
HTNDVKQLTEAVQKISQECIVIWGKTPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, V11I, G73T I13M, K20I, M36I, I62V, L63P, I64IV, C67F, A71V, I72L, P79D, I85V, T91S, I93L  
>7013-31230| codons 1-99
PQITLWQRPFITMKIGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD
QVPVEIFGHKVLTTVLVGDTPVNVVGRNLMSQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006