Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7013 | 7013-31230 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 24 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11I, G73T | I13M, K20I, M36I, I62V, L63P, I64IV, C67F, A71V, I72L, P79D, I85V, T91S, I93L |
| >7013-31230| codons 1-99 PQITLWQRPFITMKIGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD QVPVEIFGHKVLTTVLVGDTPVNVVGRNLMSQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Q151M, T215F | F116Y, K219Q | K103N, Y181C, G190A | V35VI, V60VI, V118I, K122E, M164L, Q174K, G196E, F214L, L228H, V245E, Q278N, A288T, I293V, K311R, Q334C, R356K, A360T, A376S, T377Q, S379C, K390R |
| >7013-31230| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYYSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSLTKILEPFRKKNPDIVI CQYMDDLYVASDLEIEQHRTKIEELRQHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKNLCKLLRGTKTLTEVVPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGCGQWTYQIYQEPFKNLKTGKYAKMRGT HTNDVKQLTEAVQKISQECIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |