<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7003 7003-30707 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32VI, M46MI, I47IV, I54IL, L90M L33LF L10LI, T12P, K14R, K20T, E35D, M36V, N37S, R41K, I62V, L63P, I72V, T74S, V77VI, I93L  
>7003-30707| codons 1-99
PQITLWQRPIVPIRIGGQLTEALLDTGADDTIFEDVSLPGKWKPKIVGGIGGFLKVRQYD
QVPIEICGHKAVGSVLIGPTPVNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T215F   K103KN, Y181C   K43KE, K49KR, I135T, I142IT, Q174K, I178IM, R211Q, L228R, A272P, I293IV, E297A, I326V, G333E, Q334H, T338S, G359GS, I375V, T377Q, T386I, K395R T139TKPQ
>7003-30707| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNEQPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDMVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLQWGFFTPDKKHQKEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQEHGQWSYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEAVQKVAQESIVIWGKIPKFKLPIQRETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006