Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7003 | 7003-30707 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46MI, I47IV, I54IL, L90M | L33LF | L10LI, T12P, K14R, K20T, E35D, M36V, N37S, R41K, I62V, L63P, I72V, T74S, V77VI, I93L |
| >7003-30707| codons 1-99 PQITLWQRPIVPIRIGGQLTEALLDTGADDTIFEDVSLPGKWKPKIVGGIGGFLKVRQYD QVPIEICGHKAVGSVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215F | K103KN, Y181C | K43KE, K49KR, I135T, I142IT, Q174K, I178IM, R211Q, L228R, A272P, I293IV, E297A, I326V, G333E, Q334H, T338S, G359GS, I375V, T377Q, T386I, K395R | T139TKPQ |
| >7003-30707| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNEQPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDMVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLQWGFFTPDKKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQEHGQWSYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKVAQESIVIWGKIPKFKLPIQRETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |