Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7002 | 7002-30703 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | V75L, K219R | K103N, Y188*L | A98G | K20R, V35L, K122KE, I135T, R172K, V179I, T200TA, I202V, E203D, Q207K, R211A, K223T, L228H, A272S, I293V, P294Q, K311R, V317A, G333E, M357Q, G359S, K366R, T386I |
| >7002-30703| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIII YQYVDDLLVGSDLEIGQHRAKVDELRKHLWAWGFYTPDRKHQTEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEVVQLTEEAE LELAENREILREPVHGAYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARQRSA HTNDVRQLTEAVQKIATESIVIWGKIPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48A, I54V, V82A, L90M | L33LI | L10I, K20R, E35D, M36I, N37D, D60E, I62V, L63P, A71V, I85V, I93L |
| >7002-30703| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVIEDIDLPGRWKPKLIAGIGGFVKVRQYE QVPIEICGHKVIGTVLVGPTPANIVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |