Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6378 | 6378-30930 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184MIV, L210W, T215Y | K11R, E44D, V90I, A98S, I142IV, G196AV, R211K, D237DN, A272P, K275KR, K281KR, I293V, Q334H, M357T, A371V, I375A |
| >6378-30930| codons 1-399 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEIQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIVQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPNKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCRLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEVVQKAATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48Q, V82A, I84V | L10I, I13V, G16E, K20R, M36I, G51A, I62V, L63N, A71V |
| >6378-30930| codons 1-99 PQITLWQRPIVTVKIEGQLREALLDTGADDTVLEEINLPGRWKPKIIQGIAGFIKVRQYD QVNIEICGHKVIGTVLVGPTPANVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |