Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6377 | 6377-30930 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, Y115F, M184V | T215V, K219Q | K101P, K103N | V35T, T39A, V60VI, T69N, R83K, V90I, D123E, D177E, F214L, L228H, K249Q, A272P, K277R, T286A, E297K, M357T |
| >6377-30930| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKIVDFRELNKKTQDFWEIQLGIPHPAGLPKNKSVTVLDVGDAFFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLVTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEQDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82C, L90M | F53L | L10V, I15V, G16A, R41N, L63P, H69K, A71V |
| >6377-30930| codons 1-99 PQITLWQRPVVTIKVAGQLKEALLDTGADDTVLEEMNLPGNWKPKLIGGIGGLVKVRQYD QIPIEICGKKVIGTVVVGPTPCNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |