Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6376 | 6376-30929 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | K101E, G190A | E28D, K43Q, E44D, V60I, A98S, V118I, K122E, D123E, I135K, S162SN, G196E, Q207E, R211K, D237E, V245E, A272P, K281R, E297Q, D324E, M357T, R358K, K366R, K390R, K395R, E396D, E399D |
| >6376-30929| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTDEKIKALVEICTELEQDGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIEQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPEKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVIPLTQEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVRQLTEAVQKIATESIVIWGKTPKFRLPIQRDTWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | G73S | L10I, T12P, K14R, K55R, L63P, I66V, H69K, A71V, V77I |
| >6376-30929| codons 1-99 PQITLWQRPIVPIRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVRVRQYD QIPIEVCGKKVISTVLIGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |