<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6376 6376-30929 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y V75M K101E, G190A   E28D, K43Q, E44D, V60I, A98S, V118I, K122E, D123E, I135K, S162SN, G196E, Q207E, R211K, D237E, V245E, A272P, K281R, E297Q, D324E, M357T, R358K, K366R, K390R, K395R, E396D, E399D  
>6376-30929| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTDEKIKALVEICTELEQDGKISKIGPENPYNTPI
FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI
YQYMDDLYVASDLEIEQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPEKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVIPLTQEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA
HTNDVRQLTEAVQKIATESIVIWGKTPKFRLPIQRDTWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, I84V, L90M G73S L10I, T12P, K14R, K55R, L63P, I66V, H69K, A71V, V77I  
>6376-30929| codons 1-99
PQITLWQRPIVPIRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVRVRQYD
QIPIEVCGKKVISTVLIGPTPVNVIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006