<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6375 6375-30929 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219N V106A, G190A F227L E44D, V118I, K122E, D123E, I135T, S162C, R172K, G196E, E203K, H208Y, R211K, K223Q, A272P, D324E, G335S, R356K, R358K, K366R, A371V, K390R, E399D T296I
>6375-30929| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFKKQNPDIVI
YQYVDDLYVASDLEIEQHRTKIKELRQYLWKWGFYTPDNKHQQEPPLLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLIEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQSQWTYQIYQEPFKNLKTGKYAKMKGA
HTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIQKETWDA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, I47V, I54A, V82T, L90M L33F, M46V L10I, I13V, K14R, I15V, K20R, M36I, N37D, L63P, I66F, A71V, I72V, Q92K  
>6375-30929| codons 1-99
PQITLWQRPIVTVRVGGQLREALLDTGADDTIFEEIDLPGRWKPKVVGGIGGFAKVRQYD
QIPIEFCGHKVVGTVLVGPTPTNIIGRNLMTKIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006