Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6375 | 6375-30929 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | V106A, G190A | F227L | E44D, V118I, K122E, D123E, I135T, S162C, R172K, G196E, E203K, H208Y, R211K, K223Q, A272P, D324E, G335S, R356K, R358K, K366R, A371V, K390R, E399D | T296I |
| >6375-30929| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFKKQNPDIVI YQYVDDLYVASDLEIEQHRTKIKELRQYLWKWGFYTPDNKHQQEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLIEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQSQWTYQIYQEPFKNLKTGKYAKMKGA HTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIQKETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54A, V82T, L90M | L33F, M46V | L10I, I13V, K14R, I15V, K20R, M36I, N37D, L63P, I66F, A71V, I72V, Q92K |
| >6375-30929| codons 1-99 PQITLWQRPIVTVRVGGQLREALLDTGADDTIFEEIDLPGRWKPKVVGGIGGFAKVRQYD QIPIEFCGHKVVGTVLVGPTPTNIIGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |