Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6374 | 6374-30929 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84V, L90M | L10F, L33F, Q58E, G73GS | I15V, K20R, E35D, M36IL, N37D, I62V, L63P, C67F, H69K, A71V, Q92QK |
| >6374-30929| codons 1-99 PQITLWQRPFVTIKVGGQLREALLDTGADDTVFEDLDLPGRWKPKMIGGIGGFVKVREYD QVPIEIFGKKVISTVLVGPTPANVIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K219R | K103N, Y181C, G190GA | K43Q, E44D, T69N, V118I, D123E, I135T, E138EA, S162C, G196E, E203K, Q207E, R211K, K223Q, L228R, Q242L, A272P, T286A, E297K, V317A, F346Y, G359S, T369V, T386TI, E399D |
| >6374-30929| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIEQHRTKIKELREHLWKWGFYTPDRKHQQEPPFRWMGYELHPDKWT VLPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPYKNLKTGKYARMRSA HTNDVKQLVEAVQKIATESIVIWGKIPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |