Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6373 | 6373-30926 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54A, V82A | L24I | L10I, T12P, K14R, I15V, K20R, E35D, M36I, N37D, R41K, L63P, A71V, I72V |
| >6373-30926| codons 1-99 PQITLWQRPIVPIRVGGQLREALIDTGADDTVLEDIDLPGKWKPKLIGGIGGFAKVRQYD QIPIEICGHKVVGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, V75M, L210W, T215Y | K219R | A33AG, V35L, T39K, K43Q, E44D, V118I, K122E, I135T, G196K, H208Y, R211K, K223Q, L228R, V245VM, D250DE, A272P, I293V, D324DG, G333E, G359S, A371V, A376CS, T377TI, T386I, K390KR |
| >6373-30926| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKGLLEICKELEQDGKISKIGPENPYNTPV FAIKKKDSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIKQHRTKIEELRQYLWKWGFYTPDRKHQQEPPFRWMGYELHPDKWT VQPIMLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKGLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKISIESIVIWGKIPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |