<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6373 6373-30926 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54A, V82A L24I L10I, T12P, K14R, I15V, K20R, E35D, M36I, N37D, R41K, L63P, A71V, I72V  
>6373-30926| codons 1-99
PQITLWQRPIVPIRVGGQLREALIDTGADDTVLEDIDLPGKWKPKLIGGIGGFAKVRQYD
QIPIEICGHKVVGTVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L210W, T215Y V75M, K219R     A33AG, V35L, T39K, K43Q, E44D, V118I, K122E, I135T, G196K, H208Y, R211K, K223Q, L228R, V245VM, D250DE, A272P, I293V, D324DG, G333E, G359S, A371V, A376CS, T377TI, T386I, K390KR  
>6373-30926| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKGLLEICKELEQDGKISKIGPENPYNTPV
FAIKKKDSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIKQHRTKIEELRQYLWKWGFYTPDRKHQQEPPFRWMGYELHPDKWT
VQPIMLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKGLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKISIESIVIWGKIPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006