Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6362 | 6362-30929 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, V82A | T12P, I15V, L19T, N37S, K55R, I62V, L63P, I72M, V77I, I93L, C95F |
| >6362-30929| codons 1-99 PQITLWQRPLVPIKVGGQTKEALLDTGADDTILEEMSLPGRWKPKIVGGIGGFIRVRQYD QVPIEICGHKAMGTVLIGPTPANIIGRNLLTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | T215TI, K219Q, N348IT | K103N | Y318F | K104KT, D123E, I135T, T165IM, G196E, T200Q, I202V, A272P, K277R, I293V, K311R, Q334D, G335C, R356K, M357K, K390R |
| >6362-30929| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNTSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMMKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRQKVEELRQHLLRWGFITPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILREPVHGVFYDPSKDLIAEIQKQGDCQWTYQIYQEPFKTLKTGKYAKKRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |