<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6359 6359-30929 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, L76V, V82A, L90LM L10F, Q58E I15V, L19LI, K20R, E35D, M36I, K55R, D60DE, I62V, L63P, A71V, I72V, I93L  
>6359-30929| codons 1-99
PQITLWQRPFVTIKVGGQIREALLDTGADDTVLEDINLPGRWKPKLIGGIGGFVRVREYE
QVPIEICGHKVVGTVVVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, T215F K219Q, N348I K101E, Y181C, G190A V108VI I2IV, K20R, E28A, V60VI, L109LV, S117SA, V118I, I135T, R172RK, T200TK, H208HY, F214L, D218E, L228H, Q242QH, E248V, D250E, S251Q, V292I, I293V, I329L, G359GS, A376T, T386I  
>6359-30929| codons 1-399
PVSPIETVPVKLKPGMDGPRVKQWPLTAEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTIVDVGDAYFAIPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
CQYMDDLYVASDLEIGQHRKKIEELRQYLLRWGLFTPEQKHQKEPPFHWMGYELHPDKWT
VHPIVLPVKEQWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKILKTGKYARMRSA
HTNDVKQLTEAVQKITTESIVIWGKIPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006