Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6359 | 6359-30929 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82A, L90LM | L10F, Q58E | I15V, L19LI, K20R, E35D, M36I, K55R, D60DE, I62V, L63P, A71V, I72V, I93L |
| >6359-30929| codons 1-99 PQITLWQRPFVTIKVGGQIREALLDTGADDTVLEDINLPGRWKPKLIGGIGGFVRVREYE QVPIEICGHKVVGTVVVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q, N348I | K101E, Y181C, G190A | V108VI | I2IV, K20R, E28A, V60VI, L109LV, S117SA, V118I, I135T, R172RK, T200TK, H208HY, F214L, D218E, L228H, Q242QH, E248V, D250E, S251Q, V292I, I293V, I329L, G359GS, A376T, T386I |
| >6359-30929| codons 1-399 PVSPIETVPVKLKPGMDGPRVKQWPLTAEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTIVDVGDAYFAIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI CQYMDDLYVASDLEIGQHRKKIEELRQYLLRWGLFTPEQKHQKEPPFHWMGYELHPDKWT VHPIVLPVKEQWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKILKTGKYARMRSA HTNDVKQLTEAVQKITTESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |