Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6358 | 6358-30926 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, M184V, T215F | V75T, K219Q | Y181C | E138K | K20R, V35T, V118I, K122E, I135T, T139I, K166R, R211K, F214L, D218E, L228H, A272P, V276I, L283I, I293V, E297K, D324E, G333E, G335S, K347Q, K350KR, R356K, K366R, A371V, T386I, K390R, E399ED, A400T |
| >6358-30926| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV FAIKKKNSDKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNKIPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGLFTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKIKQLCKLIRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQEQSQWTYQIYQEPFQNLRTGKYAKMRGA HTNDVRQLTEVVQKIATESIVIWGKIPKFRLPIQKETWDT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54A, I84V, L90M | L10F, L33F, N88D, L89V | T4TS, I13V, K14R, I15V, K20R, E34V, E35D, M36I, N37E, I62V, L63P, I66F, A71V, Q92R |
| >6358-30926| codons 1-99 PQISLWQRPFVTVRVGGQLREALLDTGADDTVFVDIELPGRWKPKMIGGIGGFAKVRQYD QVPIEFCGHKVIGTVLVGPTPVNVIGRDVMTRIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |