<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6358 6358-30926 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54A, I84V, L90M L10F, L33F, N88D, L89V T4TS, I13V, K14R, I15V, K20R, E34V, E35D, M36I, N37E, I62V, L63P, I66F, A71V, Q92R  
>6358-30926| codons 1-99
PQISLWQRPFVTVRVGGQLREALLDTGADDTVFVDIELPGRWKPKMIGGIGGFAKVRQYD
QVPIEFCGHKVIGTVLVGPTPVNVIGRDVMTRIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74I, M184V, T215F V75T, K219Q Y181C E138K K20R, V35T, V118I, K122E, I135T, T139I, K166R, R211K, F214L, D218E, L228H, A272P, V276I, L283I, I293V, E297K, D324E, G333E, G335S, K347Q, K350KR, R356K, K366R, A371V, T386I, K390R, E399ED  
>6358-30926| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSDKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNKIPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI
CQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGLFTPEQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKIKQLCKLIRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQEQSQWTYQIYQEPFQNLRTGKYAKMRGA
HTNDVRQLTEVVQKIATESIVIWGKIPKFRLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006