Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6357 | 6357-30926 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A, L90M | K43T | L10I, T12S, I13V, L19P, K20I, E35D, M36I, Q61HN, I62V, L63P, I64IV, I66ILM, H69R, T74S, I93L, C95F |
| >6357-30926| codons 1-99 PQITLWQRPIVSVKIGGQPIEALLDTGADDTVLEDINLPGRWTPKMIVGIGGFVKVRQYD NVPVEMCGRKAIGSVLVGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69G_SG, L210W, T215Y | A98G | P4S, K20R, W88S, K101Q, V118I, K122E, K173T, G196E, R211K, L228H, V245M, E248D, A272P, K275R, I293V, P294T, Q334E, R358K, G359S, Q367L, I375V, T386I, K390R |
| >6357-30926| codons 1-400 PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSGKWRKLVDFRELNKRTQDFSEVQLGIPHPGGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIMLPDKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKALTEVVTLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVKLLTEAVQKVATESIVIWGKIPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |