Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6356 | 6356-30925 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82CST | L24I, F53L, Q58E | L10I, N37D, D60E, Q61N, L63P, I64V, A71V, T74S, V77I, I93L | L38L_DL |
| >6356-30925| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMDLPGRWKPKIIGGIGGLVKVREYE NIPVEICGHKVIGSVLIGPTPTNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | Y188L | T39A, E44D, W88C, V106I, D123E, D177E, V179I, T200E, E203K, H208Y, R211K, K223E, D237E, A272S, T286A, E297K, Q334N, G335GS, K347KE, K350KR, R358RK, G359S, A371V, V372L, I375V, T386I |
| >6356-30925| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII YQYMDDLLVGSDLEIGQHREKIKELRQYLWKWGFYTPDKKHQEEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNSQWTYQIYQEPFENLRTGKYARMKSA HTNDVKQLTEVLQKVATESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |