<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6345 6345-30918 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y   K101P, G190A   I31V, K122E, D123E, I135V, S162C, V179I, R211K, A272P, K275KR, K277R, E291D, I293V, E297KR, P313A, Q334L, F346Y, M357T, A360T, T369V, A371V, I375V  
>6345-30918| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKVKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLPKKKSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIII
YQYVDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTDVVPLTREAE
LELAENREILKEAVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPYKNLKTGKYARTRGT
HTNDVKQLVEVVQKVATESIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, L76LV, V82F, I84V, L90LM Q58E L10V, G16A, F53Y, Q61D, L63S, H69K, V77I  
>6345-30918| codons 1-99
PQITLWQRPVVTIKIAGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGYIKVREYD
DISIEICGKKAIGTVVIGPTPFNVIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006