Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6344 | 6344-30918 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215F | D67H, K219Q | K101E, Y181C, G190A | A98G | K20R, T39A, K43E, V60I, S68N, T69N, V118I, D123E, I135V, R211K, F214L, D218E, L228H, Q242H, A272P, I293V, P294A, E297K, V317A, I329L, G333E, A360V, S379C |
| >6344-30918| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEEEGKISKIGPENPYNTPI FAIKKKHNNKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRTKIEELRQHLLKWGLFTPEQKHQKEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVALTKEAE LELAENREILKEPVHGAYYDPSKDLIAELQKQEQGQWTYQIYQEPFKNLKTGKYARMRGV HTNDVKQLTEAVQKIATECIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47IV, I54IL, L76LV, I84V, L90M | L10FI, L33I, N83D, L89V | I13V, Q18H, A22V, E35N, M36I, N37D, R41RK, K55KR, I62V, L63P, A71V |
| >6344-30918| codons 1-99 PQITLWQRPIVTVKIGGHLKEVLLDTGADDTVIENIDLPGKWKPKIVGGIGGFLRVRQYD QVPIEICGHKVIGTVVVGPTPVDVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |