<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6344 6344-30918 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, T215F D67H, K219Q K101E, Y181C, G190A A98G K20R, T39A, K43E, V60I, S68N, T69N, V118I, D123E, I135V, R211K, F214L, D218E, L228H, Q242H, A272P, I293V, P294A, E297K, V317A, I329L, G333E, A360V, S379C  
>6344-30918| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEEEGKISKIGPENPYNTPI
FAIKKKHNNKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYVDDLYVASDLEIGQHRTKIEELRQHLLKWGLFTPEQKHQKEPPFHWMGYELHPDKWT
VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVALTKEAE
LELAENREILKEPVHGAYYDPSKDLIAELQKQEQGQWTYQIYQEPFKNLKTGKYARMRGV
HTNDVKQLTEAVQKIATECIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47IV, I54IL, L76LV, I84V, L90M L10FI, L33I, N83D, L89V I13V, Q18H, A22V, E35N, M36I, N37D, R41RK, K55KR, I62V, L63P, A71V  
>6344-30918| codons 1-99
PQITLWQRPIVTVKIGGHLKEVLLDTGADDTVIENIDLPGKWKPKIVGGIGGFLRVRQYD
QVPIEICGHKVIGTVVVGPTPVDVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006