Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6342 | 6342-30918 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L210W, T215Y | D67G, K219R | K101P, K103N | V35L, K43E, V118I, K122E, S162C, I202V, Q207E, V245E, A272P, K277R, L283I, I293V, Q334N, G335S, R356K, G359GS, K390R |
| >6342-30918| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEEEGKISKIGPENPYNTPV FAIKKKGSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLPKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKVEELREHLWRWGFYTPDRKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNSQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I84V, L90M | L33F, G73A, L89V | L10I, N37D, L63P, I64L, A71T, P79S, I93L |
| >6342-30918| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTIFEEMDLPGRWKPKIVGGIGGFIKVRQYD QIPLEICGHKTIATVLVGSTPVNVIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |