<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6342 6342-30918 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I84V, L90M L33F, G73A, L89V L10I, N37D, L63P, I64L, A71T, P79S, I93L  
>6342-30918| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTIFEEMDLPGRWKPKIVGGIGGFIKVRQYD
QIPLEICGHKTIATVLVGSTPVNVIGRNVMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L210W, T215Y D67G, K219R K101P, K103N   V35L, K43E, V118I, K122E, S162C, I202V, Q207E, V245E, A272P, K277R, L283I, I293V, Q334N, G335S, R356K, G359GS, K390R  
>6342-30918| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEEEGKISKIGPENPYNTPV
FAIKKKGSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLPKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKVEELREHLWRWGFYTPDRKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNSQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006