Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6341 | 6341-30918 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, G48M, I54S, V82A, L90M | L10IV, K20R, M36I, N37D, Q61QHKN, I62V, L63T, I64V, H69K, A71V, T74S, I93L |
| >6341-30918| codons 1-99 PQITLWQRPVVTIKIGGQLREALLDTGADDTVLEEIDLPGRWKPKIIMGIGGFSKVRQYD NVTVEICGKKVIGSVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219R, N348I | T39A, K43E, E44A, K49R, E53D, V106I, V118I, K122E, D123E, S162D, K166R, D177DG, I178IM, V179I, G196E, R211K, K223KQ, L228H, V245E, A272P, K277R, L283I, I293V, E297R, I341F, R356RK, M357MT, A371V, I375M, T386I, K390R |
| >6341-30918| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEAGKISRIGPDNPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTRILEPFRKQNPGMII YQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDRKHQQEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQFYQEPFKILKTGKYAKTRGA HTNDVKQLTEVVQKMATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |