Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6329 | 6329-30924 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219N | K101P, K103N | P9PS, M16V, K20R, V35M, T39A, K43E, E44D, K73M, A98S, V118I, D123E, I135K, Y144F, S162SN, D177G, G196E, R211K, V245E, A272P, K277R, I293IV, E297R, E312Q, I326L, R356RK, M357MT, G359GS, K366R, A371AV, K390KR |
| >6329-30924| codons 1-399 PISPIETVSVKLKPGVDGPRVKQWPLTEEKIKALMEICAELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRMLMDFRELNKRTQDFWEVQLGIPHPSGLPKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSKNNETPGIRFQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPGIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE LELAENREILKQPVHGVYYDPSKDLLAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKTRSA HTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IL, I84V | L33I, N83D | L10IV, T12IV, I13AV, A22V, E35D, M36I, Q61HN, I62V, L63Q, I64V, A71AT, I72IT, T74S, V75VI, T91TS |
| >6329-30924| codons 1-99 PQITLWQRPVVVVKIGGQLKEVLLDTGADDTVIEDINLPGRWKPKMIGGIGGFLKVRQYD NVQVEICGHKTTGSILVGPTPVDVIGRNLLSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |