<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6329 6329-30924 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54IL, I84V L33I, N83D L10IV, T12IV, I13AV, A22V, E35D, M36I, Q61HN, I62V, L63Q, I64V, A71AT, I72IT, T74S, V75VI, T91TS  
>6329-30924| codons 1-99
PQITLWQRPVVVVKIGGQLKEVLLDTGADDTVIEDINLPGRWKPKMIGGIGGFLKVRQYD
NVQVEICGHKTTGSILVGPTPVDVIGRNLLSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, M184V, L210W, T215Y K219N K101P, K103N   P9PS, M16V, K20R, V35M, T39A, K43E, E44D, K73M, A98S, V118I, D123E, I135K, Y144F, S162SN, D177G, G196E, R211K, V245E, A272P, K277R, I293IV, E297R, E312Q, I326L, R356RK, M357MT, G359GS, K366R, A371AV, K390KR  
>6329-30924| codons 1-399
PISPIETVSVKLKPGVDGPRVKQWPLTEEKIKALMEICAELEEDGKISKIGPENPYNTPV
FAIKKKNSTKWRMLMDFRELNKRTQDFWEVQLGIPHPSGLPKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSKNNETPGIRFQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPGIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE
LELAENREILKQPVHGVYYDPSKDLLAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKTRSA
HTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006