Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6328 | 6328-30930 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82A, L90M | L33F, F53L, G73S | L10V, T12S, K14R, E34Q, M36L, N37D, I62V, L63P, A71V, I72T, Q92K, C95F |
| >6328-30930| codons 1-99 PQITLWQRPVVSIRIGGQLKEALLDTGADDTVFQELDLPGRWKPKIVGGIGGLVKVRQYD QVPIEICGHKVTSTVLVGPTPANIIGRNLMTKIGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219R | K20R, V35I, K43Q, E44D, V90VI, I94L, V118I, K122E, D123DN, I135T, Q197K, T200A, Q207E, H208Y, D218E, A272P, T286A, I293V, E297K, D324E, R356K, K366R, T386V, K390R, A400T |
| >6328-30930| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGLPHPAGLKKKKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGKHRAKIEELREYLWRWGFYTPERKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVRQLTEAVQKIATESIVIWGKVPKFRLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |