Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6325 | 6325-30924 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V | V11VI, L33LF, L89V | L10I, K14R, I15IV, K20KM, E35D, M36I, P39PQ, R41K, I62IV, L63P, A71T, I72V, I85V, Q92K |
| >6325-30924| codons 1-99 PQITLWQRPIITIRVGGQLMEALLDTGADDTVFEDINLQGKWKPKLIGGIGGFVKVRQYD QVPIEICGHKTVGTVLVGPTPVNVVGRNVLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | A98G | K20R, E44D, V60I, V118I, D123E, I135T, I142V, D177E, G196E, R206K, H208Y, R211K, D250E, A272P, E297K, G335S, F346Y, G359S, V365I, A371V |
| >6325-30924| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRTKIEELKQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQSQWTYQIYQEPYKNLKTGKYARMRSA HTNDIKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |