Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6318 | 6318-30925 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I84V, L90M | L10F, L33I, Q58E | T12AE, I13V, L19P, K20I, E35D, M36I, L63P, I64V, A71V, L89I, T91S, I93L | P79R |
| >6318-30925| codons 1-99 PQITLWQRPFVEVKIGGQPIEALLDTGADDTVIEDINLPGRWKPKLIGGIGGFIKVREYD QIPVEICGHKVIGTVLVGRTPVNVIGRNIMSQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | A98G | K122E, I135V, I142IV, Q174E, Q207E, V245K, I293V, E312EDKN, I329V, G333E, Q334L, M357MT, A371V, T377R, K390R, E399D |
| >6318-30925| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKNPVHGVYYDPSKDLIAEVQKQELGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEVVQKIARESIVIWGKTPKFRLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |