Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6317 | 6317-30925 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215Y | K219D | Y181C | V35M, T39A, S68G, V118I, D123E, S162D, K166R, D177E, I178M, V179I, I180V, G196E, T200A, D218DE, L228H, A272P, K277R, T286A, E297K, V317A, P345Q, F346Y, K366R, A371V, A376S, E399D |
| >6317-30925| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV FAIKKKNGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTRILEPFRKQNPEMIV CQYMDDLYVGSDLEIEQHRAKIEELRQHLWRWGFYTPEDKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEQYKNLKTGKYARMRGA HTNDVRQLTEVVQKISTESIVIWGKTPKFKLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, L76V, I84V, L90M | L10F | E34EQ, N37D, D60E, I62V, L63P, A71V, V77I, I93L |
| >6317-30925| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLQEMDLPGRWKPKIIGGIGGFLKVRQYE QVPIEICGHKVIGTVVIGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |