<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6317 6317-30925 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54L, L76V, I84V, L90M L10F E34EQ, N37D, D60E, I62V, L63P, A71V, V77I, I93L  
>6317-30925| codons 1-99
PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLQEMDLPGRWKPKIIGGIGGFLKVRQYE
QVPIEICGHKVIGTVVIGPTPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L210W, T215Y K219D Y181C   V35M, T39A, S68G, V118I, D123E, S162D, K166R, D177E, I178M, V179I, I180V, G196E, T200A, D218DE, L228H, A272P, K277R, T286A, E297K, V317A, P345Q, F346Y, K366R, A371V, A376S, E399D  
>6317-30925| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV
FAIKKKNGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTRILEPFRKQNPEMIV
CQYMDDLYVGSDLEIEQHRAKIEELRQHLWRWGFYTPEDKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEQYKNLKTGKYARMRGA
HTNDVRQLTEVVQKISTESIVIWGKTPKFKLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006