Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6314 | 6314-30917 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67NT, K70R, M184V | T215I, K219E, N348I | Y181I | V108VI | V60I, T69N, K122KE, I142V, D177E, V179I, G196E, T200A, F214L, E224D, V245T, K277KR, R284RK, T286A, I293V, M357T, A376S, T377TR, T386I, K390R, A400AT |
| >6314-30917| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKTSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII IQYVDDLYVGSDLEIEQHRAKIEELRQHLLRWGLITPDEKHQKDPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLKGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARTRGA HTNDVKQLTEAVQKISRESIVIWGKIPKFRLPIQKETWET |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, G48V, I50V, I54T, V82A | Q58E | L10V, I15V, G16A, K20R, E34A, E35D, M36I, L63P, A71V, I93L |
| >6314-30917| codons 1-99 PQITLWQRPVVTIKVAGQLREALLDTGADDTVLADINLPGRWKPKIIVGVGGFTKVREYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |